Publications in PubMed (WVH)

37. Shekhar M, Terashi G, Gupta C, Sarkar D, Debussche G, Sisco NJ, Nguyen J, Mondal A, Vant J, Fromme P, Van Horn WD, Tajkhorshid E, Kihara D, Dill K, Perez A, Singharoy A. CryoFold: Determining protein structures and data-guided ensembles from cryo-EM density maps Matter. 2021 4(10):3195-3216. doi.org/10.1016/j.matt.2021.09.004

36. Hutchison JM, Capone R, Luu DD, Shah KH, Hadziselimovic A, Van Horn WD, Sanders CR. Recombinant SARS-CoV-2 envelope protein traffics to the trans-Golgi network following amphipol-mediated delivery into human cells. J. Biol. Chem. 2021 297(2):100940. doi: 10.1016/j.jbc.2021.100940. PubMed PMID: 34237302

35. Journigan VB, Alarcón-Alarcón D, Feng Z, Wang Y, Liang T, Dawley DC, Amin ARMR, Montano C, Van Horn WD, Xie XQ, Ferrer-Montiel A, Fernández-Carvajal A. Structural and in Vitro Functional Characterization of a Menthyl TRPM8 Antagonist Indicates Species-Dependent Regulation. ACS Med Chem Lett. 2021 12(5):758-767. doi: 10.1021/acsmedchemlett.1c00001. PubMed PMID: 34055223

33. Kim M, Sisco NJ, Hilton JK, Montano CM, Castro MA, Cherry BR, Levitus M, Van Horn WD. Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing. Nat Commun. 2020 11(1):4169. doi: 10.1038/s41467-020-18026-2. PubMed PMID: 32820172 

32. Sisco NJ, Luu DD, Kim M, Van Horn WD. PIRT the TRP Channel Regulating Protein Binds Calmodulin and Cholesterol-Like Ligands. Biomolecules. 2020 10(3):478. doi: 10.3390/biom10030478. PubMed PMID: 32245175

31. Garami A, Shimansky YP, Rumbus Z, Vizin RCL, Farkas N, Hegyi J, Szakacs Z, Solymar M, Csenkey A, Chiche DA, Kapil R, Kyle DJ, Van Horn WD, Hegyi P, Romanovsky AA. Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis. Pharmacol Ther. 2020 208:107474. doi: 10.1016/j.pharmthera.2020.107474.  PubMed PMID: 31926897

30. Journigan VB, Feng Z, Rahman S, Wang Y, Amin ARMR, Heffner CE, Bachtel N, Wang S, Gonzalez-Rodriguez S, Fernández-Carvajal A, Fernández-Ballester G, Hilton JK, Van Horn WD, Ferrer-Montiel A, Xie XQ, Rahman T. Structure-Based Design of Novel Biphenyl Amide Antagonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 8 Channels with Potential Implications in the Treatment of Sensory Neuropathies. ACS Chem Neurosci. 2020 11(3):268-290. doi: 10.1021/acschemneuro.9b00404. PubMed PMID: 31850745 

29. Sisco NJ, Helsell CVM, Van Horn WD. Competitive Interactions between PIRT, the Cold Sensing Ion Channel TRPM8, and PIP2 Suggest a Mechanism for Regulation. Sci Rep. 2019 9(1):14128. doi: 10.1038/s41598-019-49912-5. PubMed PMID: 31575973 

28. Hilton JK, Kim M, Van Horn WD. Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels. Acc Chem Res. 2019 Jun 18;52(6):1643-1652. doi: 10.1021/acs.accounts.9b00075. Epub 2019 May 31. PubMed PMID: 31149807.

27. Hilton JK, Salehpour T, Sisco NJ, Rath P, Van Horn WD. Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels. J Biol Chem. 2018 Jun 15;293(24):9423-9434. doi: 10.1074/jbc.RA118.003563. Epub 2018 May 3. PubMed PMID: 29724821; PubMed Central PMCID: PMC6005438.

26. Hilton JK, Van Horn WD. New pieces to an old puzzle: identifying the warfarin-binding site that prevents clotting. Nat Struct Mol Biol. 2017 Jan 5;24(1):5-6. doi: 10.1038/nsmb.3356. PubMed PMID: 28054569.

25. Liao JY, Anosova I, Bala S, Van Horn WD, Chaput JC. A parallel stranded G-quadruplex composed of threose nucleic acid (TNA). Biopolymers. 2017 Mar;107(3). doi: 10.1002/bip.22999. PubMed PMID: 27718227.

24. Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL Jr, Meiler J, Vanoye CG, Sanders CR. Structural basis for KCNE3 modulation of potassium recycling in epithelia. Sci Adv. 2016 Sep 9;2(9):e1501228. doi: 10.1126/sciadv.1501228. eCollection 2016 Sep. PubMed PMID: 27626070; PubMed Central PMCID: PMC5017827.

23. Anosova I, Kowal EA, Sisco NJ, Sau S, Liao JY, Bala S, Rozners E, Egli M, Chaput JC, Van Horn WD. Structural Insights into Conformation Differences between DNA/TNA and RNA/TNA Chimeric Duplexes. Chembiochem. 2016 Sep 15;17(18):1705-8. doi: 10.1002/cbic.201600349. Epub 2016 Jul 29. PubMed PMID: 27347671; PubMed Central PMCID: PMC5242226.

22. Anosova I, Kowal EA, Dunn MR, Chaput JC, Van Horn WD, Egli M. The structural diversity of artificial genetic polymers. Nucleic Acids Res. 2016 Feb 18;44(3):1007-21. doi: 10.1093/nar/gkv1472. Epub 2015 Dec 15. Review. PubMed PMID: 26673703; PubMed Central PMCID: PMC4756832.

21. Rath P, Hilton JK, Sisco NH, Van Horn WD. Implications of Human Transient Receptor Potential Melastatin 8 (TRPM8) Channel Gating from Menthol Binding Studies of the Sensing Domain. Biochemistry. 2016, epub ahead of print  PMID 26653082

20. Zook J, Mo G, Sisco NJ, Craciunescu FM, Hansen DT, Baravati B, Cherry BR, Sykes K, Wachter R, Van Horn WD, Fromme P. NMR Structure of Francisella tularensis Virulence Determinant Reveals Structural Homology to Bet v1 Allergen Proteins. Structure. 2015, 23, 1116-1122. doi: 10.1016/j.str.2015.03.025. PMID: 26004443

19. Hilton JK, Rath P, Helsell CVM, Beckstein O, Van Horn WD. Understanding Thermosensitive Transient Receptor Potential Channels as Versatile Polymodal Cellular Sensors. Biochemistry. 2015, 54, 2401-2413. doi: 10.1021/acs.biochem.5b00071. PMID:25812016

18. Van Horn WD. VKORC1 ER mislocalization causes rare disease. Blood. 2014 Aug 21;124(8):1215-16. doi: 10.1182/blood-2014-07-586032. PubMed PMID: 25147380; PubMed Central PMCID: PMC4141510

17. Peng D, Kim JH, Kroncke BM, Law CL, Xia Y, Droege KD, Van Horn WD, Vanoye CG, Sanders CR. Purification and Structural Study of the Voltage-Sensor Domain of the Human KCNQ1 Potassium Ion Channel. Biochemistry. 2014 Apr 1;53(12):2032-42. doi:
10.1021/bi500102w. PubMed PMID: 24606221; PubMed Central PMCID: PMC3977583.

16. Van Horn WD. Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like 1. Crit. Rev. Biochem. Mol. Biol. 2013.  Jul-Aug;48(4):357-72. doi:10.3109/10409238.2013.791659. Epub 2013 Apr 30.

15. Barrett PJ, Chen J, Cho MK, Kim JH, Lu Z, Mathew S, Peng D, Song Y, Van Horn WD, Zhuang T, Sönnichsen FD, Sanders CR. The quiet renaissance of protein nuclear magnetic resonance. Biochemistry. 2013 Feb 26;52(8):1303-20. doi: 10.1021/bi4000436. Epub 2013 Feb 12. PubMed PMID: 23368985; PubMed Central PMCID: PMC3592982.

14. Shi M, Pedchenko V, Greer BH, Van Horn WD., Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A. Enhancing integrin ?₁ inserted (I) domain affinity to ligand potentiates integrin ?₁?₁-mediated down-regulation of collagen synthesis. J Biol Chem. 2012 Oct 12;287(42):35139-52. doi: 10.1074/jbc.M112.358648. Epub 2012 Aug 10. PubMed PMID: 22888006; PubMed Central PMCID: PMC3471707.

13. Barrett PJ, Song Y, Van Horn WD, Hustedt EJ, Schafer JM, Hadziselimovic A, Beel AJ, Sanders CR. The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol. Science. 2012 Jun 1;336(6085):1168-71. doi: 10.1126/science.1219988. PubMed PMID: 22654059; PubMed Central PMCID: PMC3528355.

12. Lu Z, Van Horn WD, Chen J, Mathew S, Zent R, Sanders CR. Bicelles at low concentrations. Mol Pharm. 2012 Apr 2;9(4):752-61. doi: 10.1021/mp2004687. Epub 2012 Jan 20. PubMed PMID: 22221179; PubMed Central PMCID: PMC3319193.

11. Van Horn WD, Sanders CR. Prokaryotic diacylglycerol kinase and undecaprenol kinase. Annu Rev Biophys. 2012;41:81-101. doi: 10.1146/annurev-biophys-050511-102330. Epub 2011 Dec 20. PubMed PMID: 22224599.

10. Van Horn WD, Vanoye CG, Sanders CR. Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel. Curr Opin Struct Biol. 2011 Apr;21(2):283-91. doi: 10.1016/j.sbi.2011.01.001. Epub 2011 Feb 4. Review. PubMed PMID: 21296569; PubMed Central PMCID: PMC3070781.

9. Kang C, Vanoye CG, Welch RC, Van Horn WD, Sanders CR. Functional delivery of a membrane protein into oocyte membranes using bicelles. Biochemistry. 2010 Feb 2;49(4):653-5. doi: 10.1021/bi902155t. PubMed PMID: 20044833; PubMed Central PMCID: PMC2811756.

8. Van Horn WD, Beel AJ, Kang C, Sanders CR. The impact of window functions on NMR-based paramagnetic relaxation enhancement measurements in membrane proteins. Biochim Biophys Acta. 2010 Feb;1798(2):140-9. doi: 10.1016/j.bbamem.2009.08.022. Epub 2009 Sep 12. PubMed PMID: 19751702; PubMed Central PMCID: PMC2812639.

7. Kim HJ, Howell SC, Van Horn WD, Jeon YH, Sanders CR. Recent Advances in the Application of Solution NMR Spectroscopy to Multi-Span Integral Membrane Proteins. Prog Nucl Magn Reson Spectrosc. 2009 Nov 1;55(4):335-360. PubMed PMID: 20161395; PubMed Central PMCID: PMC2782866.

6. Van Horn WD, Kim HJ, Ellis CD, Hadziselimovic A, Sulistijo ES, Karra MD, Tian C, Sönnichsen FD, Sanders CR. Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase. Science. 2009 Jun 26;324(5935):1726-9. doi: 10.1126/science.1171716. PubMed PMID: 19556511; PubMed Central PMCID: PMC2764269.

5. Van Horn WD, Ogilvie ME, Flynn PF. Reverse micelle encapsulation as a model for intracellular crowding. J Am Chem Soc. 2009 Jun 17;131(23):8030-9. doi: 10.1021/ja901871n. PubMed PMID: 19469539.

4. Van Horn WD, Ogilvie ME, Flynn PF. Use of reverse micelles in membrane protein structural biology. J Biomol NMR. 2008 Mar;40(3):203-11. doi: 10.1007/s10858-008-9227-5. Epub 2008 Feb 23. PubMed PMID: 18297402.

3. Flynn PF, Simorellis AK; Van Horn W D. NMR Studies of encapsulated proteins. Annu. Reports NMR Spectroscopy. 2007; 62:179-219. doi: 10.1016/S0066-4103(07)62004-3.

2. Simorellis AK, Van Horn WD, Flynn PF. Dynamics of low temperature induced water shedding from AOT reverse micelles. J Am Chem Soc. 2006 Apr 19;128(15):5082-90. PubMed PMID: 16608342.

1. Van Horn WD, Simorellis AK, Flynn PF. Low-temperature studies of encapsulated proteins. J Am Chem Soc. 2005 Oct 5;127(39):13553-60. PubMed PMID: 16190719.